By E. Lütjen-Drecoll
The phenomenon of getting older is characterised via numerous degenerative alterations, which differentially have an effect on the hugely really expert buildings in the eye, akin to the simply mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. accordingly, the attention can function a very good version method to check age-related degenerative illnesses. an summary article bargains with the molecular biology of alpha-B-crystallin, and unique articles supply additional perception into the distribution and attainable practical value of nonlenticular alpha-B-crystallin. Retinal transplantation experiences which can finally result in treatment for tapetoretinal degeneration and age-related macular degeneration are mentioned. additional, elements that impact the improvement of the retinal tissues are investigated. And one other review examines cells of the deep lens fibers. This precise factor is an in-depth resource of knowledge to ophthalmologists in learn and perform.
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Additional resources for Aging and Age Related Ocular Diseases (Ophthalmologica, 1)
In the concentration used to reduce intraocular pressure (10 –4 to 10 –3 mol/l), epinephrine contracted strips of Regulation of Trabecular Meshwork Contractility trabecular meshwork. Additional application of metipranolol, a ß-blocker, further increased trabecular meshwork tone, indicating blockage of the relaxing effect of the ßcomponent of epinephrine. It seems that the net effect of epinephrine on trabecular meshwork contractility should depend on the balance of ·- and ß-adrenergic receptors in the tissue of the species observed.
4 Radius RL, Pederson JE: Laser-induced primate glaucoma. II. Histopathology. Arch Ophthalmol 1984;102:1693–1698. 5 Quigley HA, Addicks EM: Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest Ophthalmol Vis Sci 1980;19:137–152. 6 Quigley HA, Addicks EM, Green WR, Maumenee AE: Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol 1981;99:635–649. 7 Quigley HA, Hohman RM, Addicks EM, Green WR: Blood vessels of the glaucomatous optic disc in experimental primate and human eyes.
Furuyoshi/Furuyoshi/May/Hayreh/Alm/ Lütjen-Drecoll Ophthalmologica 2000;214:33–53 Regulation of Trabecular Meshwork Contractility Friederike Stumpff Michael Wiederholt Institut für Klinische Physiologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Deutschland Key Words Glaucoma W Trabecular meshwork W Smooth muscle W Aqueous humor outflow W Contractility Abstract Ample evidence supports the theory that trabecular meshwork possesses smooth-muscle-like properties. Trabecular meshwork cells express a large number of transporters, channels and receptors, many of which are known to regulate smooth-muscle contractility.
Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll