Aging is a group-selected adaptation: theory, evidence, and by Joshua Mitteldorf PDF

By Joshua Mitteldorf

ISBN-10: 1315354039

ISBN-13: 9781315354033

ISBN-10: 1498715281

ISBN-13: 9781498715287

ISBN-10: 1498715303

ISBN-13: 9781498715300

Because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary concept, specifically within the region of genetics. simultaneously, a technology of multilevel choice has came upon its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic idea of senescence, wherein getting older has Read more...

summary: because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary thought, in particular within the quarter of genetics. simultaneously, a technological know-how of multilevel choice has came across its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic thought of senescence, wherein getting older has been affirmatively chosen since it degrees the loss of life expense over the years, aiding to stabilize inhabitants dynamics and stop extinctions

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Blagosklonny goes on to conclude that aging must be driven by signaling and goes on to describe some of the signal molecules that are known to trigger self-destruction, especially mTOR. How to reconcile this with natural selection? Blagosklonny invokes a kind of hormonal inertia, such that the expression of mTOR is favored while it is useful for growth and development, and 18 Aging is a Group-Selected Adaptation later in life it is not properly turned off. Why then is it not turned off? At this point, he invokes the standard fiction, that there has been insufficient selection against it, because “in the wild, organisms do not live long enough to experience aging.

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Aging is a group-selected adaptation: theory, evidence, and medical implications by Joshua Mitteldorf


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