By Robert Katzman, Katherine Bick
authors are imminently certified to put in writing in this subject...their first-hand wisdom of the interval in query and of the members they interview enriches the book's content material considerably.''
--Norman R. Relkin, MD, PhD in NEUROLOGY (April 2001)
''Katzman and Bick show huge interviewing abilities, and their respondents offer remarkably beneficiant and candid fabric. This ebook will accordingly fascinate scholars of the historical past of technology, despite their curiosity in Alzheimer's ailment. if you happen to have such curiosity, it's a infrequent treat.''
--John C.S. Breitner, MD, MPH, ANNALS OF NEUROLOGY (March 2001)
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Extra resources for Alzheimer Disease. The Changing View
Yes, you lose neurons but it's the lost synapses that matter. And you lose synapses ^vithout losing neurons. This ^vas sho^vn a long time ago by Arnold Scheibel. I ^vas rather friendly ^vith Scheibel at one time; he ^was fun. Anyway, he show^ed the loss of dendrites in Alzheimer's disease a long time ago and also the law^less growth that people talk about. I sa^v la^vless growth in the E M but I've never published any pictures of it. From time to time in the E M I saw lots and lots of neurites packed together, parallel in nests, each about half a micron in diameter, perhaps one quarter of a micron, thin as thin, ^ t h only one or two tubules in them, but I didn't know^ what they w^ere so I never sho^ved any pictures of them.
Penetration with osmium \vas slow. Some years later I experimented with this and I found that I could fix a -whole slice of rat forebrain in osmium but that came many years later. I -was too scared to do it then. I had enough trouble with bad fixation an3Avay as ^ve didn't have glutaraldehyde. Even now, I've picked up these blocks, the first four blocks that I've got into cutting recently, in the last 6 months, and I found that it w^as so difficult and I recalled ho^v difficult it w^as many years ago, simply because of bad fixation, so much has been improved.
A lot of people said nobody could ever do it. So I suppose we did do some good. I still don't know, and you sound as if you aren't sure either, why did the public change its mind? W h a t made people think it was a disease and not just ageing? KLB: Well, in the States, it was a well-orchestrated campaign with scientists, scientific leaders, and politicians united in a movement to influence the Congress and the electorate. But I think it worked because the moment had come and some people seized it.
Alzheimer Disease. The Changing View by Robert Katzman, Katherine Bick