Download e-book for iPad: Antimicrobial peptides : discovery, design and novel by Guangshun Wang

By Guangshun Wang

ISBN-10: 1845936949

ISBN-13: 9781845936945

Antimicrobial Peptides (AMPs), an organism's integrated security molecules, have attracted wide study consciousness world wide. Harnessing and developing them synthetically has the aptitude to assist triumph over expanding antibiotic resistance in lots of pathogens. as well as overlaying the present advances in AMP examine, this quantity examines new applied sciences comparable to bioinformatics, combinatorial libraries, high-throughput screening, peptidomimetics, biophysics, and structural biology. This quantity additionally describes new equipment and techniques for AMP prediction, layout, and purposes that conquer stumbling blocks in constructing them into healing brokers.

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De Kruijff, B. and Breukink, E. (2006) An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313, 1636– 1637. Hellekant, G. and Danilova, V. (2005) Brazzein a small, sweet protein: discovery and physiological overview. Chemical Senses 30, i88–i89. , MarcianoCabral, F. and Leippe, M. (2002) Pore-forming 19 polypeptides of the pathogenic protozoon Naegleria fowleri. Journal of Biological Chemistry 277, 22353–22360. , Msadek, T. and El Amri, C. (2009) Comparative study of two plasticins: specificity, interfacial behavior, and bactericidal activity.

Salzet, M. and Zasloff, M. (2005) The nervous system and innate immunity: the neuropeptide connection. Nature Immunology 6, 558–564. Bulet, P. and Stocklin, R. (2005) Insect antimicrobial peptides: structures, properties and gene regulation. Protein and Peptide Letters 12, 3–11. F. S. (1998) Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins. Journal of Bacteriology 180, 1988–1994. , Scalise, G. and Giacometti, A. (2008) Protective effects of the combination of alpha-helical antimicrobial peptides and rifampicin in three rat models of Pseudomonas aeruginosa infection.

2005a) Bacteriocins: developing innate immunity for food. Nature Reviews. Microbiology 3, 777– 788. , Hill, C. P. (2005b) Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147. Proceedings of the National Academy of Sciences of the USA 102, 18584–18589. , Singh, J. A. (2009) The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides. Molecular and Cellular Biochemistry 332, 43–50.

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Antimicrobial peptides : discovery, design and novel therapeutic strategies by Guangshun Wang

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